Appropriate Patients
Ideal candidates for SUPARTZ are patients with knee OA (1) who:
- Have not responded to conservative non-pharmacologic therapy, including physical therapy
- Have not responded to simple analgesics such as acetaminophen
Dosing
25 mg/2.5 mL active ingredient per syringe(1)
Directions for use
SUPARTZ is administered by intra-articular injections once a week (1 week apart) for a total of 5 injections. Some patients may experience benefit with 3 injections given at weekly intervals. This has been noted in a study in which patients treated with 3 injections were followed for 90 days. (1, 2) Injection of subcutaneous lidocaine or similar local anesthetic may be recommended prior to injection of SUPARTZ.
Recommendations for managing knee OA pain

Contraindications to SUPARTZ include (1)
- Previous allergic reactions to sodium hylaluronate products, including SUPARTZ
- Infections or skin diseases in the area where the injection will be given
- Allergies to products from birds, such as feathers, eggs, and poultry
The safety and effectiveness of SUPARTZ have not been established in pregnant women, lactating women, or children.
Patient Testimonial
Watch a short video about a patient who suffered from knee osteoarthritis and benefited from SUPARTZ, right from the first series of injections.
- SUPARTZ (package insert). Durham, NC: Bioventus LLC; 2012.
- Karlsson J, Sjögren LS, Lohmander LS. Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study. Rheumatology (Oxford). 2002;41(11):1240-1248.
- Adapted from: American College of Rheumatology. Recommendations for the medical management of osteoarthritis of the hip and knee 2000. www.rheumatology.org/practice/clinical/guidelines/oa-mgmt.asp. Accessed November 2, 2011.
- Marks R, Penton L. Are foot orthotics efficacious for treating painful medial compartment knee osteoarthritis? A review of the literature. Int J Clin Pract. 2004;58:49-57.
- Mayo Clinic. Osteoarthritis. Treatment and drugs. www.mayoclinic.com/health/osteoarthritis/DS00019/DSECTION=treatments-and-drugs. Accessed November 14, 2012.




